Water Lane in Cromford (A5012) will close next week while Derbyshire County Council carries out emergency sewer repairs.
This is to allow road resurfacing to take place between the Market Place junction to Dunsley Mill after the sewer repairs are complete.
Road markings along the road from Market Place to B5056 junction at Grangemill will also be re-painted.
Traffic will be diverted along A5012, B5056, A6, A5012 and vice versa.
The road will be closed from 9am to 3.45pm every day from Tuesday September 13 between Market Place, Cromford and Clatterway junction, Bonsall until October 7.