Ambergate were comfortably beaten after Matlock Town CFA proved too good in the second half.
Matlock weathered early Ambegate pressure before taking the lead in the 39 minute with a smart cross shot from James Byard.
Ambergate levelled in the 58th minute from Jack Ferguson’s well hit penalty.
But it was the visitors who were to finish the stronger with further goals from Reece Nuttall (62 min), Jack Yeomans (77 min) and Michael Lettall (85 min)
The defeat leaves Ambergate sixth in Division Two of the Midland Regional Allicance, while Matlock are in third spot.