James Rowe’s men could go top of the league if they win and Boreham Wood and Grimsby slip-up.
But Town could be without as many as 10 players due to injury, health and suspension.
The Blues are unbeaten at home this season with five wins and two draws in all competitions.
Here is Liam Norcliffe’s predicted Chesterfield line-up...
1. Grant Smith - GK
Back-to-back clean sheets for the Town stopper. Photo: Dean Atkins
2. George Carline - RWB
Played a part in the winner against Aldershot in midweek. Photo: Dean Atkins
3. Fraser Kerr - RCB
Chesterfield have not conceded a goal while Kerr has been on the pitch in his five appearances for the club. Photo: Tina Jenner
4. Haydn Hollis - CB
Immense in midweek, and has now signed a new contract. Photo: Dean Atkins