The French giants face the Spanish side on 27th July as part of their summer tour, which also takes in games against Norwich City and Middlesbrough.
It is a match which will feature plenty of big names and is set to attract a big crowd.
Ex Man-City and Barcelona keeper Claudio Bravo, Dimitri Payet, Argentine international Guido Rodríguez, Álex Moreno and French international Matteo Guendouzi are just some of the stars likely to be on show.
Admission details will be announced in due course.
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1. Pau Lopez - Marseille
Pau López has had spells with Real Betis and Roma and spent last season on loan with Marseille. Photo: AFP via Getty Images
2. Claudio Bravo - Real Betis
Claudio Bravo is a former Barcelona and Man City goalkeeper. He joined Betis after leaving City and won the Copa del Rey last season. Photo: Getty Images
3. Duje Caleta Car - Marseille
Centre-Back Duje Caleta-Car has played more than 100 times for Marseille and was part of the Croatian 2018 World Cup squad which lost to France in the final. Photo: AFP via Getty Images
4. Nabil Fekir - Real Betis
Nabil Fekir came through the ranks at Lyon and was named Ligue 1 Young Player of the Year in 2013. Fekir made his debut for France in March 2015 and was chosen in their squad that won the 2018 FIFA World Cup. Photo: Getty Images